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This prospective, open-label, phase 1 study (Clinicaltrials.gov, NCT01055496) investigated the tolerability profile and the recommended phase 2 dose (RP2D) regimen of InO plus R-GDP in patients with relapsed/refractory CD22+ B-cell NHL. Additional objectives included characterizing the PK and determining the preliminary antitumor activity of InO plus R-GDP. Therefore this study was undertaken in three parts: Part 1, identification of the highest dose regimen(s) with acceptable toxicity (MTD); Part 2, confirmation of the RP2D regimen(s); Part 3, RP2D expansion..
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